Technical Forum

Technical Forum: Control your genes! Tools for gene expression modification

15 March 2016 15:00 hrs. - 18:00 hrs.
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Technical Forum: Control your genes! Tools for gene expression modification

Sander BaronvanAsbeck
Jori van der Raadt
Susan Schuster
Sabine Tanis
Jan Hendrik Venhuizen


15-03-2016 15:00:0015-03-2016 18:00:00Europe/AmsterdamTechnical Forum: Control your genes! Tools for gene expression modification Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route

Remarks / more information:


undefinedJohn van der Oost, Laboratory of Microbiology, Wageningen University
Target more with the new CRISPR-variant Cpf1
Prof. Dr. John van der Oost has an extensive trackrecord in synthetic biology, modifying bacterial systems for the production of novel-energy sources, genome modification tools (including CRISPR) and gene regulation tools, including the DNA-guide DNA interference by prokaryotic Argonaut. In a very recent publication in Nature, Prof. Dr. van der Oost showed the development of an exciting new CRISPR tool, Cpf1, which further increases the possible target sites in the genome. In his talk, he will describe the new CRISPR system, with emphasis on both development and exploitation.


undefinedPietro Spitali, LUMC, Leiden
Antisense-mediated exon skipping therapy; from bench to bedside
Pietro Spitali is from the lab from Prof. Annemieke Aartsma-Rus who played an important role in the development of antisense oligonucleotide-mediated (AON) exon skipping therapy for Duchenne muscular dystrophy (DMD). Their work currently focuses on further optimizing AON therapy for DMD. This involves improving the delivery and efficiency of exon skipping compounds, studies in muscle regeneration and pathology, the identification of biomarkers, studying the basics of pre-mRNA splicing and transcript processing, and the generation of mouse models. In his talk he will share his experience of developing the AON exon skipping approach from bench to (almost) bedside and will outline how this approach can be exploited as a research tool and as a potential therapy for other diseases.


undefinedDario Lupianez, Max Planck Institute for Molecular Genetics, Berlin
Understanding structural variants by shuffeling the genome with CRISvar
Dr. Lupianez is an expert in the field of genomic topology and the effects thereof on gene expression. With particular interest in the gene regulation required for testis organogenesis, Dr. Lupianez has applied a wide variety of gene regulation techniques and has recently published a high-impact paper on a new variant on CRISPR/Cas (CRISVar), which can be used in Mice to introduce genomic structural variations (SV); including deletions, inversions and duplications. SVs are large-scale structural differences in the genomic DNA ranging from a few kilobases to entire chromosomes and contribute to a large extent to the variability of our genome and are often associated with disease. In his talk he will explain about this new technique and its possible applicability for various studies.



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