Seminar

Seminar

Date:
11 July 2011 00:00 hrs.
Location:
Title:
A critical role for the tetraspanin CD37 in regulating immune cell migration.
Speaker(s):

Ass. Prof. Mark Wright, Leucocyte Protein Laboratory, Monash University in Australia

Host(s):

Dr. Annemiek van Spriel, Department of Tumor Immunology

11-07-2011 00:00:00Europe/AmsterdamA critical role for the tetraspanin CD37 in regulating immune cell migration. Rimlsrimls@radboudumc.nl

Remarks / more information:

Mark-WrightTetraspanins are a superfamily of proteins with a critical role in organising signal-transducing microdomains at the cell surface. We have recently published that, the tetraspanins CD37 and TSSC6 regulate T cell proliferation, and peptide/MHC presentation (Gartlan K.H. et al 2010 J. Immunol 185:3158). Here, I will present data from disease models that in vivo T cell responses in CD37 and TSSC6-deficient mice (including CD37 and TSSC6 double KO mice) are poor. All tetraspanin-deficient mice are susceptible to mouse malaria (Plasmodium yoelii), and make poor T cell responses to influenza (1) and tumor challenge. These poor immune responses are not due to impairment in T cell/DC interactions, but rather impairment of dendritic cell migration. To further support the idea that tetraspanins regulate immune cell migration I will also present data from in vivo models of inflammation that demonstrate that leukocytes deficient for CD37 have a defect in adhesion to endothelium and subsequent emigration out of the vasculature.



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