Seminar

Seminar

Date:
19 January 2012 00:00 hrs.
Location:
Title:
Langerin-DTR mouse model to study Langerhans cell (LC) function and development in health and disease
Speaker(s):

Dr. Björn Clausen, Associate Professor, Department of Immunology at the Erasmus MC, Rotterdam

Host(s):

Prof. R. Sauerwein, Medical Microbiology, RUNMC

19-01-2012 00:00:00Europe/AmsterdamLangerin-DTR mouse model to study Langerhans cell (LC) function and development in health and disease Rimlsrimls@radboudumc.nl

Remarks / more information:

The main focus of the research of Björn Clausen is the analysis of dendritic cell (DC) and, in particular, Langerhans cell (LC) function and development in health and disease by different conditional gene targeting approaches. On one hand, his lab has developed the Langerin-DTR mouse model to achieve specific and inducible depletion of LCs and other Langerin expressing DC populations. On the other hand, he exploits Cre/loxP-mediated LC- and DC-specific in vivo mutagenesis to dissect the role of different signaling pathways to govern LC and DC function and differentiation.



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