Seminar

Seminar

Date:
4 April 2012 00:00 hrs.
Location:
Title:
Genomic architecture, gene regulation and human diseases
Speaker(s):

Dr. José Luis Gómez Skarmeta

Centro Andaluz de Biología del Desarrollo

Universidad Pablo de Olavide, Sevilla, Spain

Host(s):

Dr. Gert Jan Veenstra, Department of Molecular Biology, NCMLS, Nijmegen

04-04-2012 00:00:00Europe/AmsterdamGenomic architecture, gene regulation and human diseases Rimlsrimls@radboudumc.nl

Remarks / more information:

Gomez SkarmetaThe generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the non-coding DNA surrounding their target genes that became active or inactive at particular developmental stages. On the top of this, the 3D structure of the chromatin plays an essential role in facilitating the access of such cis-regulatory elements to particular promoters.  In this seminar, I will discuss the importance of the chromatin architecture and the dynamic of cis-regulatory elements during development and its implication in human diseases and genome evolution.



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