MMD Masterclass: Prof. G. Kersten

Mini Symposium: Immunotherapy: harnessing the immune system to treat disease

Date:
25 September 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Thermostable, needle-free influenza vaccines
Speaker(s):

Prof. G. Kersten;  IntraVacc Bilthoven and Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Leiden University, The Netherlands
 

Host(s):

Prof. Jolanda de Vries and Prof. Gosse Adema, Department of Tumor Immunology, NCMLS

25-09-2013 00:00:00Europe/AmsterdamThermostable, needle-free influenza vaccines Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Prof . Kersten LeidenAntigens formulated in bioneedles are a potential alternative delivery system for vaccine delivery by classical needle and syringe injection. Influenza vaccines administered by bioneedles were compared head-to-headin vivowith liquid influenza vaccinations. Bioneedle influenza vaccines induced high HI titers comparable to those after intramuscular WIV vaccination, and significantly increased the immunogenicity of subunit and virosomal vaccines. Further studies revealed that WIV vaccines induced potent T-cell responses that were skewed towards T-helper 1 responses, indicative of a strong cellular immune response. Thein vivoand stability results indicate that bioneedles are an attractive alternative to conventional liquid influenza vaccines, lack the need of a cold-chain and can be used both in epidemic as well as pandemic vaccination campaigns.



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