MMD Masterclass: Prof. Casteilla

Adipose tissue as a reservoir of immature and therapeutic cells

Date:
23 September 2014 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Adipose tissue as a reservoir of immature and therapeutic cells
Speaker(s):

Prof. L. Casteilla, STROMALab, TOULOUSE, France

23-09-2014 00:00:00Europe/AmsterdamAdipose tissue as a reservoir of immature and therapeutic cells  Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Casteilla , Louis

http://www.stromalab.fr/index.php?option=com_content&view=article&id=62&Itemid=&lang=en

 Adipose-derived stem cells (ASC) share numerous features with MSC from bone marrow and represent a good alternative and attractive source of stromal cells for clinical purposes. ASC are relatively easy to obtain from adipose tissue and in higher number compare to MSC from bone marrow. They display a greater angiogenic potential and can be grown in a defined medium as spheres including at clonal level. In recent investigations, we investigate the effects of aging on regenerative properties of ASC. We demonstrate that aging doesn't change number, phenotype, growth and differentiation of human ASC and causes little senescence. Paracrine activity of these cells is highly disturbed. Manipulating oxidative stress drive the fate of these cells and can reverse aging phenotype. We set-up a clinical trial to test the tolerance and feasibility of a treatment of critical ischmia leg with autologous ASC. The phase I/II is now finished.



<< back to all events