MMD Masterclass: Tony Yaksh

The biology underlying the tradition from an acute to a chronic pain state: Transmitters to innate immunity

Date:
19 April 2016 15:30 hrs. - 16:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
The biology underlying the tradition from an acute to a chronic pain state: Transmitters to innate immunity
Speaker(s):

Tony Yaksh, Prof. of Anesthesiology and Pharmacology, UCSD, San Diego, USA

Host(s):

Esmeralda Blaney Davidson, Dept. of Experimental Rheumatology, Radboudumc

19-04-2016 15:30:0019-04-2016 16:30:00Europe/AmsterdamThe biology underlying the tradition from an acute to a chronic pain state: Transmitters to innate immunity Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedundefinedDr. Tony L. Yaksh,  is a distinguished Professor in Anesthesiology and Pharmacology at UCSD. He is cited for his ground breaking studies on opiate action in spinal cord which rapidly led to the widespread use of epidural and intrathecal analgesics in humans to manage acute and chronic pain states. His subsequent studies provided a basis for understanding the pharmacology of the spinal gating of pain information. He is an expert on issues related to spinal drug kinetics and the evaluation of the safety of spinally delivered agents. His laboratory has been preeminent in studying the safety of spinal agents and mechanisms of their toxicity, a unique academic endeavor that has established essential criteria for spinal drug development.

 

Key Publications

  • Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. PLoS One, 6:e19126, 2011
  • Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatoryhyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc NatlAcadSci USA, 109: 6721-6726, 2012.
  • Effects of General Anesthetics on Substance P Release and c-Fos Expression in the Spinal Dorsal Horn. Anesthesiology, 2013


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