Seminar: Anne Blangy

Targeting podosome patterning in osteoclasts to prevent osteoporosis

Date:
19 April 2016 11:00 hrs. - 12:00 hrs.
Location:
Location see remarks
Title:
Targeting podosome patterning in osteoclasts to prevent osteoporosis
Speaker(s):

Anne Blangy, CRBM, Montpellier, France

Host(s):

Alessandra Cambi, Dept. of Cell Biology, RIMLS

19-04-2016 11:00:0019-04-2016 12:00:00Europe/AmsterdamTargeting podosome patterning in osteoclasts to prevent osteoporosis Location see remarksRimlsrimls@radboudumc.nl

Remarks / more information:


Location: Knowledge Square 6th floor, RIMLS Building, Route 283

undefinedundefinedOsteoporosis arises from excessive osteoclast activity that is associated with a variety of diseases. Current osteoporosis treatments efficiently stop osteoclast activity but have adverse effects. Our main focus is to investigate the molecular mechanisms controlling the podosome pattering in osteoclasts. Podosome assemble as a typical belt in osteoclasts, which is the backbone of the bone degradation apparatus. We could show that inhibition of Dock5, an exchange factor for the GTPaseRac, prevents the formation of the podosome belt, bone resorption by osteoclasts and pathological bone loss without affecting bone formation the mouse. We are working at understanding further the molecular architecture of the osteoclastpodosome belt and identifying regulators of bone resorption. 

Key Publications

  • Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclastpodosome organization while preserving bone formation. Nat Commun. 6:6218, 2015
  • The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts. J Bone Miner Res. 26:1099-110, 2011 


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