Seminar: Armagan Kocer

Ion channels: Bridging the gap between electrical properties of membranes to physiology and behavior

Date:
13 September 2016 12:30 hrs. - 13:30 hrs.
Location:
Location see remarks
Title:
Ion channels: Bridging the gap between electrical properties of membranes to physiology and behavior
Speaker(s):

Armagan Kocer, assistant professor, Department of Neurosciences, University Center Groningen (UMCG)

Host(s):

Tansu Celikel, Radboud University

13-09-2016 12:30:0013-09-2016 13:30:00Europe/AmsterdamIon channels: Bridging the gap between electrical properties of membranes to physiology and behavior Location see remarksRimlsrimls@radboudumc.nl

Remarks / more information:

undefinedIon channels are pore-forming transmembrane proteins that convert chemical or mechanical messages into electrical signals by regulating the movement of ions cross the otherwise impermeable biological membranes. In the case of excitable cells, such as neurons and muscles, ion channels are responsible for the efficient and fast electrical communication between the cells. Defects in their functioning have significant physiological and behavioral effects. With the current advances in disciplines ranging from the single molecule to behavioral sciences, we are now at a stage to understand the working mechanism of ion channels, generate new drug targets, and engineer new functions on ion channels to control the cellular communication with the ultimate goal of understanding and controlling brain function. 

 

In my talk I will mention about (1) our molecular tools to study and manipulate ion channels, (2) findings on the working mechanism of a mechanosensitive ion channel at the molecular level, and (3) how this background is applied to understand the structure and function of a human ion channel, which is involved in both spinocerebellar ataxia and sudden cardiac arrest. Next, I will show two direct applications of our engineered ion channels in the fields of nanomedicine and biosensors, especially on targeted and triggered drug delivery and early disease diagnosis. The talk will end with the future perspectives of an integrated program that could bridge the gap between ion channel structure-function to physiology and behavior.

Location: room HG00.068, Radboud University

 



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