Seminar Dr. A. Gimenez-Cassina

Mitochondrial metabolism in the brain and its impact on neuronal survival and excitability

Date:
5 June 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Mitochondrial metabolism in the brain and its impact on neuronal survival and excitability
Speaker(s):

Dr. Alfredo Gimenez-Cassina, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA

Host(s):

Prof. J. Smeitink, department of Pediatrics, RUNMC

05-06-2013 00:00:00Europe/AmsterdamMitochondrial metabolism in the brain and its impact on neuronal survival and excitability Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Alfredo Gimenez CassinaNeurons require exquisite coordination and large amounts of energy in order to carry out their functions, including fine-tuning of ion homeostasis; synthesis, release and reuptake of neurotransmitters; and constant remodeling of synaptic architecture. Mitochondria play a central role by supplying energy as ATP, buffering intracellular calcium, maintaining redox balance and providing intermediate metabolites to serve as precursors of neurotransmitters and other intracellular messengers. Importantly, compelling evidence has underscored that the selectivity of the metabolic program executed at mitochondria may contribute to modulation of different aspects of neuronal biology through mechanisms that are not yet fully understood. In this regard we have shown how manipulation of mitochondrial metabolism in the brain can lead to altered neuronal excitability and ultimately survival. This may have important implications for the treatment of neurological disorders, including neurodegenerative diseases and disorders involving alterations in neuronal activity, such as epilepsy.



<< back to all events