Seminar: Dr. Alexander Stark

Decoding transcriptional regulation

11 May 2015 11:00 hrs. - 12:00 hrs.
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Decoding transcriptional regulation

Dr. Alexander Stark, Research Institute of Molecular Pathology, Vienna, Austria 


Dr. Jo Zhou, Dept. of Molecular Biology, RIMLS

11-05-2015 11:00:0011-05-2015 12:00:00Europe/AmsterdamDecoding transcriptional regulation Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route

Remarks / more information:

undefinedIn higher eukaryotes, genes are expressed dynamically in complex spatial and temporal patterns for setting up body plans and defining specific cell-types. Each cell is able to read the regulatory information in promoter and enhancer sequences to express specific sets of genes. Here I am presenting our work towards understanding the regulatory code in Drosophila by an interdisciplinary approach. We characterize regulatory sequences by enhancer screens and computational motif analyses coupled to supervised machine-learning methods. We dissect the combinatorics of transcription factors and transcriptional cofactors at enhancers by directed tethering in enhancer complementation assays, which revealed functionally distinct classes of transcription factors and cofactors.


Key Publications: 

  • Enhancer-core-promoterspecificityseparatesdevelopmental and housekeeping gene regulation. Nature. 518:556-9, 2015
  • Genome-scalefunctionalcharacterization of Drosophiladevelopmentalenhancers in vivo. Nature. 512:91-5, 2014

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