Seminar: Dr. Aubrey de Grey

Rejuvenation biotechnology: the sweet spot between prevention and treatment of aging

21 May 2015 16:00 hrs. - 17:00 hrs.
Hippocrates room, route 77
Rejuvenation biotechnology: the sweet spot between prevention and treatment of aging

Dr. Aubrey de Grey, Chief Science Officer, SENS Research Foundation, USA


Dr. Giel Bosman and Prof. Marcel Olde Rikkert, Radboudumc

21-05-2015 16:00:0021-05-2015 17:00:00Europe/AmsterdamRejuvenation biotechnology: the sweet spot between prevention and treatment of aging Hippocrates room, route

Remarks / more information:

undefinedAging seems so ubiquitous and inevitable that we mostly don’t think of it as a medical problem, or contemplate the possibility that we could prevent it with medicine. But in fact, all the diseases of old age are parts of aging, and we don’t think that way about those. In my lecture I will explain why both “aging itself” and all the diseases of old age can, in the foreseeable future, be brought under complete medical control. This will be achieved by a panel of interventions that repair the damage of aging: in other words, that restore the molecular and cellular structure of our tissues to how they were in early adulthood. Examples include using stem cells to replace cells that the body does not replace automatically when they die, and cleaning out molecular waste products that accumulate because the body has no machinery to destroy them.

Key Publications

  • Strategies for engineered negligible senescence. Gerontology; 59:183-9, 2013. 
  • Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity? Bioessays; 27:436-46, 2005
  • Time to talk SENS: critiquing the immutability of human aging. Ann NY AcadSci; 959:452–462, 2002
  • The Mitochondrial Free Radical Theory of Aging, (LandesBioscience), 1999
  • Ending Aging (St. Martin's Press), 2008 
  • TED Global talk: A Roadmap to End Aging, 2005
Aubrey de Grey is a well recognized expert in aging research, with an exciting sense of optimism concerning the potency of current medical research in beating the cellular and molecular damage mechanisms in aging. Though he is best known for his provocative statement that the person who will live up to a thousand years already is already among us, dr. De Grey has many important other messages for all scientists interested in the future of research on molecular mechanisms of aging, degeneration and regeneration. 

In this talk he will highlight how basic research in aging may use stem cells to improve  systemic repair mechanisms. Moreover, in relation to to the specific expertise of the Radboudumc in mitochondrial disease, dr. de Grey will elaborate on the crucial role of mitochondrial metabolism and mitochondrial DNA in aging, and how to address these in rejuvenation or anti-aging interventions.

So, if you want to be up to date in rejuvenation research, you cannot afford missing this free lecture. There will be ample room for discussion, and dr De Grey will also give a TEDlike talk at our Festival OUDNIEUWS in the evening, starting from 1900 at the Lindenberg (the full programme of this event can be seen, and tickets can be reserved at …..).


Dr. Aubrey de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based  charity dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He received his BA and Ph.D. from the University of Cambridge in 1985 and 2000 respectively. His research interests encompass the characterisation of all the accumulating and eventually pathogenic molecular and cellular side-effects of metabolism (“damage”) that constitute mammalian aging and the design of interventions to repair and/or obviate that damage. Dr. de Grey is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organisations.

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