Seminar: Dr. Barry Bochner

Cell Energetics and Cancer Metabolism Analysis with Phenotype MicroArrays

Date:
22 April 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Energetics and Cancer Metabolism Analysis with Phenotype MicroArrays
Speaker(s):

Dr. Barry R. Bochner, Ph.D., CEO & CSO, Biolog, Inc., Hayward, CA

Host(s):

Dr. Bas Dutilh, Department of CMBI, RUNMC

22-04-2013 00:00:00Europe/AmsterdamEnergetics and Cancer Metabolism Analysis with Phenotype MicroArrays Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Bochner, BarryPhenotype MicroArray (PM) technology allows a biologist to assay hundreds or thousands of phenotypes of a cell line in a single experiment, to gain a comprehensive overview of cell physiology and metabolic pathway activities.  It provides phenomic information that is complementary to transcriptomic, proteomic, and metabolomic analysis and often more easy to interpret and more useful.  The PM technology platform is applicable to a wide range of cells including bacterial, fungal, or animal and provides a powerful tool for genotype-phenotype studies.  For example, it can be used for (1) analyzing mutant cells to determine the biological effects of genetic differences, (2) studying cell metabolism and metabolic regulation, (3) understanding the interplay of environment and hormonal signals on cell metabolism, (4) optimizing cell culture conditions, and (5) looking at the effects of anti-cancer drugs and other drugs and chemicals on cells.  For human cells, the assays of energy metabolism pathways are particularly useful.  The PM assays can help define both the normal and aberrant metabolism of primary cells or cell lines from various organs and tissues, aiding studies of diabetes, obesity and nutrition.  Changes in energy metabolism are also important in aging, cancer (the Warburg Effect), mitochondrial function and diseases, and toxicology. Additionally, the PM assay technology can provide critical information for studies on cell line stability, stem cell and progenitor cell differentiation, and culture medium optimization for research and industrial cell culture.

If you would like to meet with Dr. Bochner (before or after his presentation) please contact Bas Dutilh: B.Dutilh@ncmls.ru.nl

 



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