Seminar: Dr. Bart Smeets

Tracing the fate of epithelial cells in renal pathology

Date:
24 March 2014 00:00 hrs.
Location:
Location see remarks
Title:
Tracing the fate of epithelial cells in renal pathology
Speaker(s):

Dr. Bart Smeets, Medizinische Klinik II, Nephrologie, Universitätsklinikum der RWTH Aachen, Aachen, Germany

Host(s):

Prof. Han Krieken, Dept. of Pathology

24-03-2014 00:00:00Europe/AmsterdamTracing the fate of epithelial cells in renal pathology Location see remarksRimlsrimls@radboudumc.nl

Remarks / more information:

Bart Smeets Foto vierkantProgressive kidney disease is characterized by glomerulosclerosis, the final common pathway toward end stage renal disease. Glomerulosclerosis is associated with loss of podocytes and characterized by formation of scar lesions within the glomeruli. We studied the pathogenesis of glomerulosclerosis using the state-of-the-art technology of permanent genetic tagging and lineage tracing of the glomerular epithelial cells. Our studies revealed that the parietal epithelial cells are crucially involved in the formation and progression of glomerulosclerosis.

In addition, we used cell fate tracing to study the origin of regenerating proximal tubular cells after acute kidney injury. Acute kidney injury is characterized by loss of the epithelial cells of the nephrons. However, these cells have a high regenerative potential, which has led to the discussion whether or not regeneration is mediated by stem or progenitor cells. Fate tracing experiments in mice revealed that the regeneration of proximal tubular cells was mediated by surviving proximal epithelial cells, that acquired a less differentiated "scattered tubular cell" phenotype, rather than by a pre-existing progenitor/stem cells population within the kidney.

Location: Dept. of Pathology, route 812



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