Seminar: Dr. Duncan Odom

Enhancer evolution in twenty mammals

Date:
9 December 2014 14:00 hrs. - 15:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Enhancer evolution in twenty mammals
Speaker(s):

Dr. Duncan Odom, Group leader, Cambridge Research Institute, Cambridge, UK

Host(s):

Dr. Klaas Mulder, Dept. of Developmental Molecular Biology, RIMLS

09-12-2014 14:00:0009-12-2014 15:00:00Europe/AmsterdamEnhancer evolution in twenty mammals Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Odom , Duncan 1Abstract:
The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across twenty mammals from six diverse orders by profiling genomic enrichment of acetylation of H3K27 and trimethylation of H3K4. We report that rapid evolution of enhancers is a universal feature of mammalian genomes: across all study species half of all liver enhancers are unique to a single species. Most of these recently-evolved enhancers arise from exaptation of ancestral DNA, and not from lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully conserved across our study species. Our data further reveal that recently-evolved enhancers can be significantly associated with genes under positive selection, demonstrating a powerful approach to annotating regulatory adaptations in newly sequenced genomes. These results provide unprecedented insight into the functional genetics underpinning mammalian regulatory evolution.

Biography:
Duncan Odom  compares how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer. His team uses numerous new high-throughput methods combined with analysis of multiple mammals and vertebrates to reveal fundamental biological insights into tissue-specification and genome evolution.

Key Publications:

  • Cooperativity and rapid evolution of cobound transcription factors in closely related mammals. Cell 154:530-40, 2013
  • Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages. Cell 148:335-48, 2012
  • Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science 328:1036-40, 2010

 



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