Seminar: Dr. Erik Danen

Hitting a moving target – new insights in cancer cell metastasis and therapy resistance

Date:
19 November 2012 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Hitting a moving target – new insights in cancer cell metastasis and therapy resistance
Speaker(s):

Dr. Erik HJ Danen, Division of Toxicology, Leiden University NL

Host(s):

Dr. Alessandra Cambi, Department of Tumor Immunology

19-11-2012 00:00:00Europe/AmsterdamHitting a moving target – new insights in cancer cell metastasis and therapy resistance Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

DanenThe ability of cancer cells to resist chemo- or radiotherapy is a major obstacle in the treatment of patients. Cancer cell killing through accumulated DNA damage is the mechanism of action of such therapies. Work will be presented in which RNAi screening, transcriptomics, and phosphoproteomics are integrated to reveal the orchestrated DNA damage response (DDR) signaling network in stem cells. New pathways controlling the outcome of the DDR in stem and/or cancer cells and their implication in chemo- and radio-resistance are discussed.

One strategy that has been proposed for chemo- or radio-sensitization involves targeting the integrin family of transmembrane receptors. Integrins sense physical and chemical properties of the extracellular matrix and provide (cancer) cells with pro-survival signals. Experiments will be discussed that point to strikingly opposing roles for integrins in tumor growth and metastasis. Depending on the cellular context integrins appear to serve as metastasis suppressors through their ability to regulate a signaling network in control of epithelial characteristics.



<< back to all events