Seminar: Dr. Esther de Jong

Tissue dendritic cells in immunity and tolerance

Date:
18 November 2014 11:00 hrs. - 12:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Tissue dendritic cells in immunity and tolerance
Speaker(s):

Dr. Esther de Jong, Dept. of Cell Biology & Histology, AMC Amsterdam.

Host(s):

Dr. Annemiek van Spriel, Dept. of TIL, RIMLS

18-11-2014 11:00:0018-11-2014 12:00:00Europe/AmsterdamTissue dendritic cells in immunity and tolerance Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Jong De , EstherMy research is focussed on the role of dendritic cells (DCs) in the initiation and shaping of immune responses. My ongoing fascination is how DCs distinguish classes of pathogens and  polarize the development of required effector types of T cells. Our initial studies (JI 2002) have developed into several related research lines within the concept that antigen-specific T cells are activated by pathogen-primed DCs and programmed to support the appropriate class of  innate response to  clear the invading pathogen. Since their initial description in 2006 in the mouse, the mechanisms underlying induction of human Th17 cells have been enigmatic and an important theme in my research. In 2007, we described an important role for the pattern recognition receptor NOD2 in their induction, associated with inflammatory bowel disease. Subsequently, we showed that opsonisation of bacteria by IgG enhances the IL-17-promoting capacity of DCs (Blood 2011). This was followed up by the demonstration that Th17 priming requires alternative co-stimulation (Blood 2011, 2012). Apart from the focus on human Th17-development, also the functional specialization of DCs holds my strong interest. During the last decade I have become an expert on isolating DCs from various tissues and dissecting their specific function with respect to CD4+ or CD8+ T cell activation and polarization (JACI 2011, JID 2013, Human Vaccine Immunother 2013, J Leukocyte Biol 2012, JImmunol Cutting Edge 2011). We have also developed a culture system to study the function of mucosal CD103+ DCs (Mucosal Immunol 2014).

Keypublications:

  • Bakdash G, Vogelpoel LT, van Capel TM, Kapsenberg ML, de Jong EC (2014). Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells.Mucosal Immunol.Jul 16.
  • van der Aar AMG, Picavet DI, Muller F, de Boer L, van Capel TMM, Zaat SAJ, Bos JD, Janssen H, George TC, Kapsenberg ML, van Ham SM, Teunissen MBM*, de Jong EC*(2013) Langerhans Cells Favor Skin Flora Tolerance through Limited Presentation of Bacterial Antigens and Induction of Regulatory T Cells. J. Invest. Dermatol.133:1240-9
  • van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, Hommes DW, Zaat SAJ, Kapsenberg ML*, de Jong EC* (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote Interleukin-17 production in human memory T cells. Immunity 27: 660-9


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