Seminar: Dr. Florian Markowetz

Dissecting Cancer Heterogeneity

Date:
11 December 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Dissecting Cancer Heterogeneity
Speaker(s):

Dr. Florian Markowetz, University of Cambridge, CRUK Cambridge Institute, Cambridge, UK

Host(s):

Dr. Klaas Mulder, department of Molecular Developmental Biology, NCMLS

11-12-2013 00:00:00Europe/AmsterdamDissecting Cancer Heterogeneity  Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

 

Markowetz , FlorianI will talk about computational methods to address heterogeneity of breast and ovarian cancer at different levels:

(i) At the *population* level breast cancer appears in different subtypes and I will talk about our recent work on finding 10 different manifestations of the disease. 

(ii) At the *patient* level, different cancer sites can differ significantly in the genomic aberrations they carry. I will discuss how to quantify intra-patient heterogeneity by rigorous analysis of multiple patient samples.                   

(iii) At the *sample* level we often find cancer cells mixed with immune cells, stromal cells and others. This mixture of cells leads to a mixture of signals when DNA, RNA, or proteins are measured in these samples. I will present an automated and quantitative approach that leverages image analysis of histopathological images to estimate cellular composition and complement genomic profiling.

Publications:

  • Master regulators of FGFR2 signalling and breast cancer risk 
    M.N.C. Fletcher*, M.A.A. Castro*, X. Wang, I. de Santiago, M. O'Reilly, S-F. Chin, O.M. Rueda, C. Caldas, B.A.J. Ponder, F Markowetz^, K.B. Meyer^ 
    Nature Communications 4:2464 (2013) 
  • Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling 
    Y. Yuan, H. Failmezger, O.M. Rueda, H.R. Ali, S. Gräf, S-F. Chin, R.F. Schwarz, C Curtis, M.J. Dunning, H. Bardwell, N. Johnson, S. Doyle, G. Turashvili, E. Provenzano, S. Aparicio, C. Caldas, F. Markowetz 
    Science Translational Medicine, 4, 157ra142 (2012) 
  • Systems-level dynamic analyses of fate change in murine embryonic stem cells 
    R. Lu, F. Markowetz, R.D. Unwin, J.T. Leek, E.M. Airoldi, B.D. MacArthur, A. Lachmann, R. Rozov, A. Ma'ayan, L.A. Boyer, O.G. Troyanskaya, A.D. Wetton, I.R. Lemischka. 
    Nature. 2009 Nov 19;462(7271):358-362 

 



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