Seminar: Dr. Gijs Goossens

Oxygen and diabetes

8 January 2014 00:00 hrs.
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Oxygen and diabetes

Dr. Gijs Goossens, department of Human biology, Maastricht UMC, NL


Prof. Peter Deen, department of Physiology, Radboudumc

08-01-2014 00:00:00Europe/AmsterdamOxygen and diabetes Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route

Remarks / more information:


MMD Course: Oxygen in health and disease

Goossens , GijsThe current obesity epidemic is accompanied by a proportionate increase in a multitude of diseases, including type 2 diabetes, cardiovascular disease and certain types of cancer. We are just beginning to understand why many but not all obese people develop these complications. Adipose tissue (fat tissue) is more than a passive fat storage depot. In fact, this organ takes up and secretes many factors involved in whole-body metabolism, including lipids. It is therefore not surprising that adequate functioning of adipose tissue is extremely important to maintain metabolic health. Insulin resistance, a decreased responsiveness to the hormone insulin, is an early hallmark in the development of type 2 diabetes. It is now generally accepted that impaired adipose tissue function in obesity, rather than an excessive fat mass per se, represents a key step in the development of insulin resistance and type 2 diabetes. The reason for this is that enlargement of adipocytes (fat cells) in obese individuals, which is stimulated by excessive energy intake, promotes inflammation and decreases the ability of adipocytes to store even more lipids, leading to lipid accumulation in other organs such as skeletal muscle and the liver and, consequently, insulin resistance. Taken together, adequate adipose tissue function is instrumental to metabolic health. However, the driver that initiates the metabolic and endocrine derangements in adipose tissue remains unknown. Recent evidence points towards involvement of adipose tissue oxygen tension in obesity-related complications.

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