Seminar: Dr. Giulia Rancati

Role of stress and genome instability in cancer evolution and development of chemotherapy resistance

Date:
21 October 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Role of stress and genome instability in cancer evolution and development of chemotherapy resistance
Speaker(s):

Dr. Giulia Rancati, Institute of Medical Biology, A-Star, Singapore

Host(s):

Prof. Mihai Netea, department of Internal Medicine, Radboudumc

21-10-2013 00:00:00Europe/AmsterdamRole of stress and genome instability in cancer evolution and development of chemotherapy resistance Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Rancati , GiuliaEvolvability, the remarkable capacity to adapt to a variety of hostile conditions, is one of the most fascinating hallmarks of all forms of life. While we marvel at unicellular organisms evolving complex traits to survive in the most extreme places on earth, we struggle with the incredible ability of cancer cells to escape growth inhibitory signals or develop resistance to treatments. This fundamental ability of cells to adapt to genetic, environmental and chemical perturbations is best understood as adaptive evolutionary processes, in which cells tinker with existing cellular networks in order to achieve adaptive innovation. The long-term goal of my lab is to combine cell biology and systems biology approaches in order to understand cellular evolvability in mechanistic terms.



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