MMD Masterclass

DNA methylation landscapes of normal and neoplastic hematopoietic cells

Date:
3 April 2014 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
DNA methylation landscapes of normal and neoplastic hematopoietic cells
Speaker(s):

Dr. Iñaki Martin-Subero, University of Barcelona / IDIBAPS, Barcelona, Spain

Host(s):

Dr. Joost Martens,  Department of Molecular Biology, RIMLS

03-04-2014 00:00:00Europe/AmsterdamDNA methylation landscapes of normal and neoplastic hematopoietic cells  Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

InakiDuring the last decades, DNA methylation has been the subject of multiple studies in the field of hematological neoplasms, being tumor suppressor gene silencing through promoter hypermethylation the most widely reported finding. The recent development of unbiased tools allowing us to quantify methylation levels throughout the genome are now modifying our perception on the role(s) of DNA methylation during cell differentiation and neoplastic transformation. In this seminar, the speaker will present data generated in the context of the BLUEPRINT project on DNA methylomes of normal and neoplastic B cells.


Key Publications:

  • Genetic and epigenetic basis of chronic lymphocytic leukemia. Curr Opin Hematol. Jul 2013.
  • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet. Nov 2012.
  • New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood. Mar 2009.

 



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