Seminar: Dr. José Silva

Mechanisms of nuclear reprogramming

Date:
11 February 2015 15:30 hrs. - 16:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Mechanisms of nuclear reprogramming
Speaker(s):

Dr. José Silva, Wellcome Trust - MRC Stem Cell Institute, University of Cambridge, UK

Host(s):

Prof. Gert-Jan Veenstra, Dept.of Molecular Development Biology, RIMLS

11-02-2015 15:30:0011-02-2015 16:30:00Europe/AmsterdamMechanisms of nuclear reprogramming  Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Silva , Jose 2The aim of our lab is to understand the underlying biology of the conversion of a somatic epigenome back into a pluripotent epigenome, a process known as induced pluripotency. We are particularly interested in determining the molecular mechanisms by which the key players in this process work. Fully understanding induced pluripotency and better characterising iPS and ES cells is indispensible before these can be used in biomedical applications.

 

 

 

Key Publications
•Mbd3/NuRD facilitates transcription factor induced pluripotency in a context dependent
manner. Cell Stem Cell; 15:102-10, 2014.
•NANOG amplifies STAT3 activation and they synergistically induce the naïve pluripotent program. Current Biology. 24, 1-7, 2014.
•Do all roads lead to Oct4? The emerging concepts of induced pluripotency. Trends in Cell Biology; 24:275-84, 2014.



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