Seminar: Dr. Judith Paridaen

The cell biology of stem cell fate decisions in neurogenesis: Primary cilia tip the scales?

Date:
28 April 2015 10:00 hrs. - 11:00 hrs.
Location:
Location see remarks
Title:
The cell biology of stem cell fate decisions in neurogenesis: Primary cilia tip the scales?
Speaker(s):

Dr. Judith Paridaen, Wieland B. Huttner group, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany

Host(s):

Prof. Ronald Roepman, Dept. of Human Genetics, Radboudumc

28-04-2015 10:00:0028-04-2015 11:00:00Europe/AmsterdamThe cell biology of stem cell fate decisions in neurogenesis: Primary cilia tip the scales? Location see remarksRimlsrimls@radboudumc.nl

Remarks / more information:

Control of stem cell division modes is important to ensure generation of properly sized tissues during development as well as adult tissue homeostasis and repair. Asymmetric stem cell divisions balance stem cell self-renewal and differentiation as the mother cell gives rise to two unequal daughter cells. These different fates can be induced by unequal segregation of organelles and cell fate determinants between daughter cells. We recently showed that membrane derived from primary cilia, which are key sensory organelles, is retained by one of the centrosomes throughout mitosis in dividing neural stem cells. The ciliary membrane remnant is inherited mainly by the stem cell daughter cell that re-establishes a cilium before its sister cell. Therefore, I propose that asynchronous ciliogenesis and the subsequent asymmetric ciliary signalling are important in acquiring different daughter cell fates in asymmetrically dividing stem cells.

Key publications:

  • Neurogenesis during development of the vertebrate central nervous system. Embo reports. 15:351-64, 2014.
  • Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell. 155:333-44, 2013.
  • Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination. Development. 139:95-105, 2012. 

 

 Location: N. Tulpzaal, A-building route 606. 



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