Seminar: Dr. Michael Cohen

Dopamine synchronizes neural networks over time and space

17 April 2015 10:30 hrs. - 11:30 hrs.
Location see remarks
Dopamine synchronizes neural networks over time and space

Dr. Michael Cohen, University of Amsterdam, The Netherlands


Prof. Guillén Fernandez, Cognitive Neuroscience, Donders Institute, Nijmegen

17-04-2015 10:30:0017-04-2015 11:30:00Europe/AmsterdamDopamine synchronizes neural networks over time and space Location see

Remarks / more information:

Location: Colloquium Room (Red Room) Kapittelweg 29, Trigon Building

undefinedDopamine (DA) is crucial for many aspects of healthy behaviour and cognition, and disruptions in the DA system are implicated in a surprisingly wide range of disorders from major depression to addiction to schizophrenia to Parkinson's disease. Most of the research on DA has focused on its role in reward-seeking behaviour and executive functioning, or on its action at the synapse (LTP/D, for example). Relatively little is known about how DA affects intermediate-scale neural circuit dynamics and synchronization. The overarching aim of the proposed research is to test the novel hypothesis that phasic activation of the midbrain DA system creates brief temporal windows for synchronization within the cortical-striatal-hippocampal networks that are responsible for executive functioning, memory formation, and emotion regulation. The experiments will combine optogenetic DA stimulation, electrical cortical microstimulation, receptor antagonists, and voltammetry to manipulate and measure the DA system with high spatiotemporal precision; and simultaneous electrophysiological recordings from hundreds of electrodes in topologically matching cortical-striatal-hippocampal networks. The result of this 5-year research (completed by a team of four scientists) will be a new understanding of how DA rapidly modulates synchronization of the large-scale brain networks that are crucial for cognition, emotion, and learning.

Key pubications:

• Effects of time lag and frequency matching on phase-based connectivity. J Neurosci Methods. S0165-0270(14)00322-7, 2014
•Top-down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation. Hum Brain Mapp. 33:246-52, 2012

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