Seminar Dr. Rachel Giles

Oxygen and kidney tumors: molecular mechanisms

Date:
7 January 2014 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Oxygen and kidney tumors: molecular mechanisms
Speaker(s):

Dr. Rachel Giles, department of Nephrology, UMC Utrecht, NL

Host(s):

Prof. Peter Deen, department of Physiology, Radboudumc

07-01-2014 00:00:00Europe/AmsterdamOxygen and kidney tumors: molecular mechanisms Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

 

MMD Course: Oxygen in health and disease

Rachel _Giles1Most cells in the human body can't survive for long without oxygen-the element we gulp in with every breath is vital to building molecules, carrying out chemical reactions, and storing energy. But cancerous cells aren't like other cells in the body. Many tumors, in fact, thrive under conditions of low oxygen, called hypoxia. And tumors depleted of oxygen have been found, time and time again, to be more dangerous, faster growing, faster spreading, and more resistant to treatments than other tumors. Why? Cells have built in programs that put them into crisis mode when oxygen levels in their neighborhood drop; altering their metabolism to make it more efficient, turning off cell death pathways in a desperate attempt to survive, and spurring the growth of new blood vessels toward the area. This hypoxia-induced ultra-survival program is just what tumor cells need to help them evade death and grow uncontrollably. Kidney cancer, in particular, is even initiated by defects in oxygen-sensing, and is considered the cleared example of how these pathways drive cancer. 



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