Seminar: Dr. Stefan Hoppler

Seminar: Dr. Stefan Hoppler

Date:
2 July 2012 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Wnt signal and inhibitor regulate heart development; in embryos, stem cells and the computer
Speaker(s):

Dr. Stefan Hoppler, Institute of Medical Sciences, University of Aberdeen, Scotland, U.K.

Host(s):

Prof. Gert Jan C. Veenstra, Department of Molecular Developmental Biology

02-07-2012 00:00:00Europe/AmsterdamWnt signal and inhibitor regulate heart development; in embryos, stem cells and the computer Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Hoppler StefanWnt signalling is a key regulator of heart development and subsequent cardiomyocyte differentiation. We had identified Xenopus Wnt6 as an endogenous regulator of heart muscle differentiation. Prompted by systems modelling, we seared for additional regulators and found an extracellular Wnt inhibitor sFRP1, which is expressed in the differentiating myocardium in order to inhibit Wnt6 and promote normal heart muscle differentiation. Our findings show that heart muscle development in Xenopus is regulated by a negative feedback gene regulatory loop. 

Recent preliminary results using human Embryonic Stem Cells suggest that the role of Wnt signalling and possibly sFRP1 is conserved in human heart differentiation, which may be relevant for promoting regeneration of injured heart muscle.



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