Seminar: Dr. Steven Altschuler

Interpreting Cellular Heterogeneity

Date:
24 April 2013 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Interpreting Cellular Heterogeneity
Speaker(s):

Dr. Steven Altschuler, Green Center for Systems Biology, UT Southwestern Medical Center, Dallas, Texas, USA

 

Host(s):

Dr. Klaas Mulder, Department of Molecular Developmental Biology, NCMLS

 

24-04-2013 00:00:00Europe/AmsterdamInterpreting Cellular Heterogeneity Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

altschuler, StevenGenetically and morphologically identical cells can exhibit very different biochemical states. Cellular plasticity, the ability of cells to transition among states, is highly controlled in the homeostasis and regeneration of healthy tissues. Yet, when control mechanisms are lost, cellular plasticity can drive disease progression and promote drug resistance, notably in cancer. We currently focus on the origins and functional consequences of how tissue microenvironment and oncogenic progression lead to diversification of cellular phenotypes. We apply quantitative imaging approaches to investigate cellular plasticity and heterogeneity within model systems, including colonic stem cells, liver lobules, and adenocarcinomas of the colon and lung.

 



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