Seminar: Hergen Spits

Innate Lymphoid Cells: Effectors and regulators of innate immunity and tissue remodelling

Date:
1 September 2015 15:00 hrs. - 16:00 hrs.
Location:
Location see remarks
Title:
Innate Lymphoid Cells: Effectors and regulators of innate immunity and tissue remodelling
Speaker(s):

Hergen Spits, Dept. Cell Biology @ Histology, AMC Amsterdam, The Netherlands

Host(s):

Robert Sauerwein, Dept. of Medical Microbiology, RIMLS

01-09-2015 15:00:0001-09-2015 16:00:00Europe/AmsterdamInnate Lymphoid Cells: Effectors and regulators of innate immunity and tissue remodelling Location see remarksRimlsrimls@radboudumc.nl

Remarks / more information:


Location: CDL, G. Grooteplein 29, route 231

undefinedundefinedILC comprise a recently defined group of lymphocytes that mediate a range of effector and regulatory activities affecting tissue immunity at barrier surfaces, tissue homeostasis and repair and fat metabolism. ILC are grouped in three subsets ILC1, ILC2 and ILC3 which show striking similarity to T helper cell subsets in terms of cytokine secretion patterns and dependence on transcription factors. I will give an overview of current knowledge of ILC, in particular of human ILC and will discuss recent data indicating that ILC are highly plastic cells that can change their properties in a context dependent way.

 

 

Key publications:

  • The biology of innate lymphoid cells. Nature, 517, 293–301, 2015
  • Human innate lymphoid cells. Blood, 124, 700–709, 2014
  • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nature Immunology, 14, 221–229, 2013


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