Seminar: Jaap van Buul

Dynamic leukocyte – endothelial cell interactions: a local affair

4 July 2017 13:00 hrs. - 14:00 hrs.
Location see remarks
Dynamic leukocyte – endothelial cell interactions: a local affair

Jaap D. van Buul, Sanquin research, Amsterdam


Alessandra Cambi, dept. of Cell Biology, RIMLS

04-07-2017 13:00:0004-07-2017 14:00:00Europe/AmsterdamDynamic leukocyte – endothelial cell interactions: a local affair Location see

Remarks / more information:

undefinedWhen leukocytes leave the circulation, they have to cross the vessel wall by penetrating the endothelial monolayer, either through the cell-cell junctions, i.e. paracellularly, or through the cell body, i.e. transcellularly. At this point, the endothelium actively participates by inducing a local F-actin-rich ring, mediated by the small GTPase RhoA, that acts as an elastic strap to limit vascular leakage during leukocyte passage.



Recent publications:

  1. “Leukocyte Breaching of Endothelial Barriers: The Actin Link.” Alon R, van Buul JD. Trends Immunol. 2017
  2. “Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution.”Kroon J, Heemskerk N, Kalsbeek MJT, de Waard V, van Rijssel J, van Buul JD. Mol Biol Cell. 2017
  3. “F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.”Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, van Unen J, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD. Nat Commun. 2016

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