Seminar: Janine Schuurman

Inspired by nature: translating basic science to antibody therapeutics

Date:
13 April 2017 13:00 hrs. - 14:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Inspired by nature: translating basic science to antibody therapeutics
Speaker(s):

Janine Schuurman, Vice President Research at GenMab, Utrecht

Host(s):

Matthijs Jore, Dept. of Medical Microbiology, RIMLS

13-04-2017 13:00:0013-04-2017 14:00:00Europe/AmsterdamInspired by nature: translating basic science to antibody therapeutics Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedAntibody-mediated targeted therapies represent a highly effective and very successful therapeutic product strategy. At Genmab we aim to create and develop differentiated antibody therapeutics for the treatment of cancer. The seminar will focus on two case studies translating basic science to antibody therapeutics. Case study 1 is about our deep molecular insights into human IgG4 biology which resulted in an versatile bispecific antibody platform, the DuoBody technology. Case study 2 is about our HexaBody technology, which aims to potentiate antibody effector activity. This technology resulted from our research performed at understanding the mechanism of complement activation.

Download flyer

 

Key publications

  • A Novel Platform for the Potentiation of Therapeutic Antibodies Based onAntigen-Dependent Formation of IgG Hexamers at the Cell Surface. PLoS Biol; 14e1002344, 2016
  • Complement is activated by IgG hexamers assembled at the cell surface. Science; 343(6176):1260-3, 2014
  • Efficient generation of stable bispecific IgG1by controlled Fab-arm exchange. Proc Natl Acad Sci U S A.; 110(13):5145-50, 2013
  • Anti-inflammatory activity ofhuman IgG4 antibodies by dynamic Fab arm exchange. Science; 317(5844):1554-7, 2007


<< back to all events