Seminar: Janos Peti-Peterdi

Renal physiology is key to understand and augment nephron repair

Date:
24 August 2016 11:00 hrs. - 12:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Renal physiology is key to understand and augment nephron repair
Speaker(s):

Janos Peti-Peterdi, Departments of Physiology and Biophysics, and Medicine at the University of Southern California, Los Angeles, USA

Host(s):

Peter Deen, Dept. of Physiology, RIMLS

24-08-2016 11:00:0024-08-2016 12:00:00Europe/AmsterdamRenal physiology is key to understand and augment nephron repair Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedRenal macula densa (MD) cells play key sensory and regulatory functions in classic renal physiology, in the maintenance of body fluid and electrolyte homeostasis and blood pressure and is central to my research interests. These metabolism and salt-sensing MD cells are strategically positioned at the entrance of the glomerulus and, using serial intravitalmultiphoton microscopy of the same intact kidney region over several days, we obtained life visual evidence that the MD cells have a novel and exciting role in renal tissue repair with glomerular injury. this led us to the unconventional hypothesis that MD cells are master regulators of tissue remodeling in the adult kidney. Targeting this new MD mechanism may provide therapeutic benefit and result in improved kidney structure and function in chronic kidney disease, which affects one in every ten adults and for which appropriate medication is lacking. Our exciting discovery and radically new and innovative investigative approach will be presented in this renal theme seminar. Prof. Peti-peterdi was the recipient of the prestigious 2015 Young Investigator Award of the American Society of Nephrology/American Heart Association. 

Key Publications

  • Newly stemming functions of macula densa-derived prostanoids. Hypertension; 65:987-8, 2015
  • Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med.; 19:1661-6, 2013

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