Seminar: Jesmond Dalli

Novel mediators and mechanisms in resolution of infections and tissue regeneration: immunoresolvents

Date:
4 October 2016 13:15 hrs. - 14:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Novel mediators and mechanisms in resolution of infections and tissue regeneration: immunoresolvents
Speaker(s):

Jesmond Dalli, William Harvey Research Institute, Queen Mary University of London, London, UK

Host(s):

Colin Logie, Dept. of Molecular Biology, RIMLS

04-10-2016 13:15:0004-10-2016 14:00:00Europe/AmsterdamNovel mediators and mechanisms in resolution of infections and tissue regeneration: immunoresolvents Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

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Flyer

 

Specialized pro-resolving mediators are an evolutionarily conserved class of signaling molecules formed in cells by the stereoselective enzymatic conversion of polyunsaturated fatty acids. They orchestrate inflammation resolution and tissue regeneration by limiting neutrophil infiltration and stimulating macrophage phagocytosis and phenotype switching. 

 

 

 

Key Publications

  • Group-3 Innate lymphoid cells and PCTR1 govern phagocyte response and infectious resolution via neuronal control. Immunity. In press.
  • Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015
  • Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proc Natl Acad Sci U S A. 2014


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