Seminar: José Luis Gómez-Skarmeta, theme Reconstructive and regenerative medicine

Gene regulation dynamics and chromatin architecture during development and evolution

Date:
23 March 2016 09:30 hrs. - 10:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Gene regulation dynamics and chromatin architecture during development and evolution
Speaker(s):

José Luis Gómez-Skarmeta, Spanish Research Council (CSIC), Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Sevilla, Spain

Host(s):

Jo Zhou, Dept. of Molecular Developmental Biology & Human Genetics, Radboudumc

23-03-2016 09:30:0023-03-2016 10:30:00Europe/AmsterdamGene regulation dynamics and chromatin architecture during development and evolution Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedTemporal and evolutionary dynamic of gene expression is critical for tissue formation during animal development and has been essential for morphological diversification along evolution. This depends on cis-regulatory information located at the non-coding DNA. What is the dynamic of this regulatory information along development and evolution and how this information is organized in the genome? Here I will present a comparative study of the vertebrate epigenome during development that reveals an evolutionary conserved process at cis-regulatory regions essential for vertebrate body plan formation. In addition, I will show the evolutionary history of the 3D chromatin architecture of critical genomic loci.     

Key Publications

  • Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. PNAS 112:7542-7547, 2015.
  • A single 3D chromatin compartment in amphioxus reveals stepwise evolution of vertebrate Hox bimodal regulation. Nature Genetics, in press, 2016.


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