Seminar: Keerthi Krishnan, theme Sensory disorders

Uncovering aberrant plasticity in mouse models of Rett Syndrome, a neurodevelopmental disorder

Date:
8 March 2016 16:00 hrs. - 17:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Uncovering aberrant plasticity in mouse models of Rett Syndrome, a neurodevelopmental disorder
Speaker(s):

Keerthi Krishnan, Cold Spring Harbor Laboratory, New York, USA

Host(s):

Nael Nadif Kasri, Dept. of Cognitive Neuroscience

08-03-2016 16:00:0008-03-2016 17:00:00Europe/AmsterdamUncovering aberrant plasticity in mouse models of Rett Syndrome, a neurodevelopmental disorder Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedMutations in the MeCP2 cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms. Although many models of Rett Syndrome have been established, identifying primary molecular and cellular changes and tracing their impact on circuit alterations that underlie behavioral deficits has been challenging. We have utilized classical critical period plasticity and novel pup retrieval behavior to elucidate the role of MECP2 in synaptic plasticity during early postnatal development and adulthood, respectively. We find that MECP2 regulates the timing of experience-dependent plasticity in primary sensory cortices via common mechanisms targeting the parvalbumin+ GABAergic network. These results identify key molecular changes in a defined cell type and link aberrant plasticity mechanisms to functional deficits in models of neuropsychiatric disorder. 

Key Publications

  • MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex. Proc NatlAcadSci USA;112: E4782-91, 2015.  
  • PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest.; 125: 3163-77, 2015 


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