Seminar: Lucas Pelkmans, theme Cancer development and immune defence

Origins of cellular heterogeneity

17 November 2015 14:00 hrs. - 15:00 hrs.
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Origins of cellular heterogeneity

Lucas Pelkmans, ETH Zurich, Switzerland


Klaas Mulder, Dept. of Molecular Developmental Biology, RIMLS

17-11-2015 14:00:0017-11-2015 15:00:00Europe/AmsterdamOrigins of cellular heterogeneity Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route

Remarks / more information:

undefinedCells do not operate in isolation, but create heterogeneous social contexts, to which they adapt their phenotypic behaviour . This is true for single-cell organisms as well as for cells from multicellular organisms. The effect of this type of cell-to-cell variability on shaping the phenotypic spectrum of single cells has major consequences for how we study cellular processes and interpret molecular mechanisms and activities in single cells. It also shows that basic social properties of mammalian cells can be studied in in vitro experimental systems using cells grown in culture. 


Key publications:

  • Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature; 523:88-91, 2015 
  • A hierarchical map of regulatory genetic interactions in membrane trafficking. Cell; 157:1473-87, 2014 
  • Image-based transcriptomics in thousands of single human cells at single-molecule resolution. Nat Methods; 10:1127-33, 2013

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