Seminar: Marian F. Young

Small proteoglycans: Versatile regulators of bone formation, function and repair

Date:
9 March 2017 12:00 hrs. - 13:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Small proteoglycans: Versatile regulators of bone formation, function and repair
Speaker(s):

Marian F. Young, National Institutes of Health, Bethesda, MD, USA 

Host(s):

Peter van der Kraan, Dept. of Exp. Rheumatology, RIMLS

09-03-2017 12:00:0009-03-2017 13:00:00Europe/AmsterdamSmall proteoglycans: Versatile regulators of bone formation, function and repair Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedDr. Young heads Molecular Biology of Bones and Teeth Section with the overall goal to understand the function of extracellular matrix (ECM) proteins produced by bones and teeth. Dr. Young’s current research strategy focuses on a single category of ECM proteins known as small leucine-rich proteoglycans (SLRPs) that were selected based on their high level of expression in skeletal tissues. The research approach entails creating mice deficient in one or more SLRPs and examining the resulting phenotypes at the structural, cellular and molecular levels. These mice acquire numerous skeletal abnormalities and thereby serve as models that mimic human skeletal diseases including osteoporosis, osteoarthritis and ectopic (abnormal) bone formation. Her ultimate aims are to ascertain the molecular cascades that contribute to skeletal disease processes caused by SLRP deficiencies with the goal of providing a foundation for future studies designed develop ways to ameliorate skeletal disease processes. In her lecture, Dr. Young will present recent advances in understanding the function of the SLRP biglycan in bone grow, function and repair. 

Key Publications

  • Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A. 108:17022-7, 2011
  • WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J Bone Miner Res.193-208, 2011

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