Seminar: Orson Moe

A klotho-centric view of kidney disease

Date:
4 July 2016 16:00 hrs. - 17:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
A klotho-centric view of kidney disease
Speaker(s):

Orson W. Moe, University of Texas Southwestern Medical Center, USA

Host(s):

René Bindels, Dept. of Physiology, RIMLS

04-07-2016 16:00:0004-07-2016 17:00:00Europe/AmsterdamA klotho-centric view of kidney disease Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedKlotho is a circulating protein produced primarily in the kidney and exerts multiple housekeeping and cytoprotective effects on many organs. Acute kidney injury (AKI) and chronic kidney disease (CKD) are common conditions that exert grave impacts on health. Klotho deficiency is a hallmark of kidney disease and recent data show that this pathogenic for chronic progression of, and cardiovascular complications in CKD, and transition to CKD post-AKI. Klothopathobiology provides novel diagnostic, prognostic, and therapeutic potentials in the horizon for kidney disease. 

 

 

Key Publications:

  • Renal Production, Uptake, and Handling of Circulating αKlothoJ Am Soc Nephrol. 27:79-90, 2016
  • Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol. 26:1290-302, 2015
  • α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol. 307:L566-75, 2014

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