Seminar: Petra Hajkova, theme Cancer development and immune defence

The dynamics of DNA modifications during epigenetic reprogramming in vivo

Date:
5 April 2016 14:00 hrs. - 15:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
The dynamics of DNA modifications during epigenetic reprogramming in vivo
Speaker(s):

Petra Hajkova, MRC Clinical Science Centre, Imperial College London, UK

Host(s):

Klaas Mulder, Dept. of Molecular Developmental Biology, RIMLS

05-04-2016 14:00:0005-04-2016 15:00:00Europe/AmsterdamThe dynamics of DNA modifications during epigenetic reprogramming in vivo Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedEpigenetic reprogramming encompasses changes in nuclear architecture and epigenetic modifications, eventually leading to a shift in gene expression profile. At the molecular level, such a process is connected with the erasure of epigenetic marks including DNA methylation and histone modifications. Our laboratory uses in vivo models to elucidate molecular mechanisms underlying naturally occurring reprogramming events. The knowledge gained allows us to design in vitro experimental systems and to use biochemical approaches to investigate further molecular details.

 

Key Publications 

  • De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat Cell Biol, 2016
  • Continuous histone replacement by Hira is essential for normal transcriptional regulation and de novo DNA methylation during mouse oogenesis. Mol cell, 19;60, 611-25, 2015


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