Seminar: Prof. Houtsmuller and Dr. Slotman

Studying molecular mechanisms of DNA repair, gene transcription and cell migration by nanoscopy

Date:
28 January 2015 13:30 hrs. - 14:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Studying molecular mechanisms of DNA repair, gene transcription and cell migration by nanoscopy
Speaker(s):

Prof. A. Houtsmuller & Dr. J. Slotman, Erasmus OpticalImaging Centre, Erasmus MC, Rotterdam

Host(s):

Dr. Alessandra Cambi, Dept. of Tumor Immunology, RIMLS

28-01-2015 13:30:0028-01-2015 14:30:00Europe/AmsterdamStudying molecular mechanisms of DNA repair, gene transcription and cell migration by nanoscopy  Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

HoutsmullerSlotmanThe regulation and structural requirements of vital nuclear processes such as DNA replication, transcription, RNA processing and DNA repair inside the eukaryote nucleus are poorly understood. Engagement of nuclear proteins in these processes requires
transport of the involved proteins to their sites of activity (e.g. DNA-damage or specific base pair sequences). At those sites, proteins or precursor complexes are assembled into large DNA-protein
holo-complexes for at least the time of their action. Limited knowledge exists about the nature and timing of these events, about the composition of precursor-complexes and about the mode and efficiency of their transport to specific sites.

Our aim is to unravel the dynamics of macromolecular interactions required for these nuclear processes in living cells.




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