Seminar: Prof. Alexander Steinkasserer

CD83 and tolerance induction mechanisms in transplantation and autoimmunity

Date:
19 November 2012 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
CD83 and tolerance induction mechanisms in transplantation and autoimmunity
Speaker(s):

Prof. Alexander Steinkasserer, University Hospital Erlangen

Host(s):

Prof. Carl Figdor, Department of Tumor Immunology

19-11-2012 00:00:00Europe/AmsterdamCD83 and tolerance induction mechanisms in transplantation and autoimmunity Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

SteinkassererModulation of immune responses is one of the major aims in transplantation and autoimmunity. In recent years we investigated the immune-modulatory properties of the soluble CD83 molecule (sCD83) using transplantation- (i.e. skin, heart, cornea) as well as models for autoimmune disorders (i.e. EAE, IBD). Interestingly, using the high risk cornea transplantation model, sCD83 was able to prolong graft survival not only after systemic, but therapeutically even more relevant, also after topical application. The therapeutic effect was accompanied by an increase in the frequency of regulatory T cells and was mediated by the immune-regulatory enzyme IDO.Similar effects were obtained in heart and skin transplantations. Using EAE- and IBD-models we could show that sCD83 inhibits paralyses as well as inflammatory bowel disease symptoms, respectively. Thus, these findings open new treatment avenues for immune-modulation in transplantation as well as for autoimmune disorders. Finally, data regarding the identification and characterization of the cell type- and stage-specific human DC-specific CD83 promoter and its implications for next generation cancer DC-vaccination strategies will be presented.



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