Seminar: Prof. Alpha Yap

Cadherin signaling: a new role for the cytoskeleton

Date:
26 May 2015 12:30 hrs. - 13:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Cadherin signaling: a new role for the cytoskeleton
Speaker(s):

Prof. Alpha Yap, Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia

Host(s):

Prof. Peter Friedl, Dept. of Cell Biology, RIMLS

26-05-2015 12:30:0026-05-2015 13:30:00Europe/AmsterdamCadherin signaling: a new role for the cytoskeleton Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedE-cadherin adhesion functions with the actin cytoskeleton to control epithelial organization in health and disease. Conventionally, we have thought that cadherin signaling regulates the cytoskeleton to control epithelial integrity and dynamics. It has recently become apparent that cytoskeletal proteins, such as Myosin IIA, act as tumor suppressors. In this seminar I will present new evidence that cross-talk can go in the opposite direction: where the cytoskeleton determines junctional signaling. This provides new perspectives on how the cytoskeleton may influence tumor biology.

 

 

 

Key Publications

  • N-WASP regulates the epithelialjunctionalcytoskeletonby a non-canonicalpost-nucleationmechanism. Nature Cell Biology 13: 934-943, 2011
  • Centralspindlin and α-cateninregulateRhosignaling at the epithelialzonulaadherens. Nature Cell Biology 14: 818-828, 2012 


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