Seminar: Prof. Anne S. Ulrich

Protein-lipid interactions in membranes

Date:
22 October 2012 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Protein-lipid interactions in membranes
Speaker(s):

Prof. Anne S. Ulrich, Institute of Biological Interfaces (IBG2), Karlsruhe Institute of Technology (KIT), Germany

Host(s):

Prof. Roland Brock, Department of Biochemistry, NCMLS, Nijmegen

22-10-2012 00:00:00Europe/AmsterdamProtein-lipid interactions in membranes Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Ulrich, AnneWhen exploring the function of membrane proteins it is important to consider not only the structure of the protein but also its interactions with the surrounding lipid molecules. Based on a systematic variation of specific membrane properties in reconstituted model systems, studied by solid-state NMR and other biophysical techniques, it has been possible to extract several functionally relevant parameters that seem to play important roles evenin vivo. For instance, the bilayer thickness was found to affect the dimerization of tyrosine-kinase receptors via hydrophobic mismatch, with important implications on their sub-cellular localization and activity. In another context, the intrinsic curvature of the lipid bilayer was found to determine the responsiveness of the membrane towards pore-forming peptides, which are used as antimicrobial or cell penetrating agents. Finally, some recent examples will be presented on the unexpected occurrence and functional relevance of multiple salt bridges in the hydrophobic interior of a lipid membrane.



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