Seminar: Prof. Chuan He

Reversible RNA and DNA methylation in gene expression regulation

Date:
16 June 2015 14:00 hrs. - 15:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Reversible RNA and DNA methylation in gene expression regulation
Speaker(s):

Prof. Chuan He, Dept. of Chemistry, University of Chicago, USA

Host(s):

Prof. Michiel Vermeulen, Dept. of Molecular Biology, RIMLS

16-06-2015 14:00:0016-06-2015 15:00:00Europe/AmsterdamReversible RNA and DNA methylation in gene expression regulation Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedOur research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, cell biology, bioinorganic chemistry, structural biology, microbiology, and genomics. We probe the pathways and mechanisms of nucleic acids modification and demodification. We study virulence and antibiotic resistance regulation in human pathogens. We also study selective metal ion recognition and sensing by naturally occurring and engineered proteins, and live-cell imaging of metal ions and other small molecules such as H2S, heme, and CO.

 

 

 


Key Publications

  • N(6)-methyldeoxyadenosinemarksactivetranscription start sites in chlamydomonas. Cell; 161:879-92, 2015
  • N6-methyladenosine-dependent regulation of messenger RNA stability, Nature; 505:117-20, 2014
  • Genome-wideprofiling of 5-formylcytosine revealsitsroles in epigeneticpriming. Cell; 153:678-91, 2013


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