Seminar: Prof. Claus-Michael Lehr

Targeting nanomedicines to epithelial barriers: Intestines, skin and lung

Date:
18 May 2015 10:00 hrs. - 11:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Targeting nanomedicines to epithelial barriers: Intestines, skin and lung
Speaker(s):

Prof. Claus-Michael Lehr, Helmholtz-Institute for Pharmaceutical Research Saarland, Saarland University, Saarbrücken, Germany

Host(s):

Prof. Roland Brock, Dept. of Biochemistry, Radboudumc

18-05-2015 10:00:0018-05-2015 11:00:00Europe/AmsterdamTargeting nanomedicines to epithelial barriers: Intestines, skin and lung Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedundefinedThe focus of our research over the past few years has been on the epithelial barriers of the gastro-intestinal tract, the skin and the lungs. Whiles these outer biological barriers of the human body are the major routes for non-invasive drug delivery in general, they may also sometimes represent important therapeutic targets by themselves, in particular in the context of inflammatory and infectious diseases. This presentation will highlight some of our recent work in these three areas, either concerning the development of new in-vitro models or of new drug carriers systems, for which the nano-size often has turned out to be advantageous.

Key publications:

  • Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc NatlAcadSci U S A. 109, 18355-60, 2012 
  • Pulmonary drug delivery: from generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges. Lancet Respir Med. 1, 402-13, 2013.  


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