Seminar: Prof. Daniel Olive

The interaction between BTLA and HVEM negatively regulates human Vg9Vd2 T cell proliferation: a poten-tial way of immune escape for lymphoma cells

Date:
10 January 2013 00:00 hrs.
Location:
Title:
The interaction between BTLA and HVEM negatively regulates human Vg9Vd2 T cell proliferation
Speaker(s):

Prof. Daniel Olive, Department of Tumor Immunology, Institut Paoli Calmettes, Marseille, France.

Host(s):

Dr. Harry Dolstra, Laboratory of Hematology, NCMLS.

10-01-2013 00:00:00Europe/AmsterdamThe interaction between BTLA and HVEM negatively regulates human Vg9Vd2 T cell proliferation Rimlsrimls@radboudumc.nl

Remarks / more information:

  

Daniel -Olive -vierkantThe regulation of the immune system is controlled by many cell surface receptors. A prominent representative is the 'molecular switch' HVEM (herpes virus entry mediator) that can activate either proinflammatory or inhibitory signaling pathways. HVEM ligands belong to two distinct families: the TNF-related cytokines LIGHT and lymphotoxin-α, and the Ig-related membrane proteins BTLA and CD160. HVEM and its ligands have been involved in the pathogenesis of various autoimmune and inflammatory diseases, but recent reports indicate that this network may also be involved in tumor progression and resistance to immune response. Here we summarize the recent advances made regarding the knowl-edge on HVEM and its ligands in cancer cells, and their potential roles in tumor progression and escape to immune re-sponses. Blockade or enhancement of these pathways may help improving cancer therapy.



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