Seminar: Prof. Giovanna Lombardi

The long and winding road towards clinical transplantation tolerance

Date:
11 December 2012 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
The long and winding road towards clinical transplantation tolerance
Speaker(s):

Prof. Giovanna Lombardi, Professor in Human Transplant Immunology, MRC Centre in Transplantation, NIHR Biomedical Research Centre, Transplant Them, King's College London, UK

Host(s):

Dr. Hans Koenen, Department of Laboratory Medicine, RUNMC Nijmegen

11-12-2012 00:00:00Europe/AmsterdamThe long and winding road towards clinical transplantation tolerance Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

LombardiAbout Professor Giovanna Lombardi

Giovanna Lombardi obtained her PhD from the University of Rome, Italy in 1981. In 1987 she joined the Department of Immunology at the Hammersmith Hospital. Then in 2005 she joined King's College London as a Non-clinical Reader in the Department of Nephrology and Transplantation.

 

 

Research interests

We want to study the mechanisms that lead to the induction of tolerance in the context of transplantation to then translate our findings for immunotherapy. The major projects that we are involved in are the following:

  • Investigating the phenotype and function of regulatory T cells (Tregs): new markers; subpopulations of Tregs; interaction with their target cells; effect of inflammation.
  • Manipulating in vitro or targeting of antigen to dendritic cells (DCs) in vivo to induce tolerance.
  • In vitro manipulation of Tregs to generate antigen-specific Tregs for immune therapy: human and mouse Tregs; use of retroviral constructs to confer specificity; ex vivo expansion with immature DCs.

Publications

A list of  Professor Lombardi's publications and reviews can be found on the PubMed website.



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