Seminar: Prof. Gunnar Schotta

Silencing of endogenous retroviruses is essential for development

Date:
19 May 2015 15:30 hrs. - 16:30 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Silencing of endogenous retroviruses is essential for development
Speaker(s):

Prof. Gunnar Schotta, LMU Munich, Adolf ButenandtInstitut, Munich, Germany

Host(s):

Dr. Hendrik Marks, Dept. of Molecular Biology, RIMLS

19-05-2015 15:30:0019-05-2015 16:30:00Europe/AmsterdamSilencing of endogenous retroviruses is essential for development Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedundefinedEpigenetic mechanisms regulate multiple aspects of normal development (stem cell maintenance, differentiation). Misregulation of epigenetic programs can result in aberrant development (cancer, aging). In this context we study the mechanisms of epigenetic gene regulation using a combination of mouse genetics, cell biology and biochemical approaches. 

 

 Key Publications:

  • Suv4-20h2 mediates chromatin compaction and is important for cohesinrecruitment to heterochromatin. Genes Dev; 2013   
  • Suv4-20h histonemethyltransferasespromoteneuroectodermaldifferentiationbysilencing the pluripotency-associated Oct-25 gene. PLoS Genet; 9:e1003188, 2013 
  • A chromatin-widetransition to H4K20 monomethylationimpairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev; 22: 2048-2061, 2008


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