Seminar: Prof. Juliette Legler

Understanding the role of endocrine disrupting chemicals and their effects on gene regulation in obesity

Date:
15 June 2015 14:00 hrs. - 15:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Understanding the role of endocrine disrupting chemicals and their effects on gene regulation in obesity
Speaker(s):

Prof. Juliette LeglerInstitute for Environmental Studies, VU University Amsterdam, the Netherlands

Host(s):

Dr. Leonie Kamminga, Dept. of Molecular Biology, RIMLS

15-06-2015 14:00:0015-06-2015 15:00:00Europe/AmsterdamUnderstanding the role of endocrine disrupting chemicals and their effects on gene regulation in obesity Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedundefinedObesity is a multifactorial disorder characterized by excess fat storage in adipose tissue. It is influenced by genetic as well as environmental factors. Early developmental exposures to chemicals may play a role in the onset of adult obesity as epigenetic, structural and functional adaptive responses regulating energy metabolism and adipogenesis may be disturbed. We are developing a zebrafish model of obesity to examine the effects of developmental exposure to endocrine disrupting chemicals (EDCs) on adiposity. Our research indicates that EDCs such as pesticides and flame retardants may work through multiple mechanisms, such as activation of the peroxisome proliferator-activated receptor gamma (Pparg) pathway which plays a central role in adipocyte differentiation, as well as alteration of circadian rhythms. Our research also indicates that effects of EDCs on adipogenesis are accompanied by changes in DNA methylation. The identification of “obesogenic” chemicals and their effects on epigenetic gene regulation may provide important insights into the development of environmentally-induced metabolic disease. 

Key Publications

  • An integrated approach to assess the role of chemical exposure in obesity. Obesity. 21:1084-1085, 2013
  • Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47. Environ Sci Technol. 48:4110-9, 2014
  • Dynamics of DNA hydroxymethylation in zebrafish. Zebrafish. 12:230-7, 2015

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