Seminar: Prof. Robert Walker

Mechanisms of Drug nephrotoxicity – a clinical approach

Date:
13 March 2014 00:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Mechanisms of Drug nephrotoxicity – a clinical approach
Speaker(s):

Prof. Robert James Walker, Dunedin School of Medicine, University of Otago, New Zealand

Host(s):

Prof. Peter Deen, Dept. of Physiology, Radboudumc

13-03-2014 00:00:00Europe/AmsterdamMechanisms of Drug nephrotoxicity – a clinical approach Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

Walker -robI will cover the basic mechanisms of why the kidney is prone to drug induced injury and will highlight this with a number of key drugs that represent different pathways for injury.

Prof Walker is a clinical and academic nephrologist with extensive experience in the areas of clinical and experimental cardiovascular research with a particular emphasis on cardiovascular risk factors in chronic kidney disease and hypertension. Areas of research interest include cardiovascular risk factors associated with renal disease; hypertension, obesity and inflammation; the impact of insulin resistance on cardiovascular risk factors; drug induced nephrotoxicity; the impact of drugs and exercise on kidney function; the pathophysiology of the peritoneal membrane; and genetics in renal disease. This research has resulted in more than 195 refereed journal papers. He is the director of 'The Kidney in Health and Disease' Research group based at the University of Otago.

Key Publications:

  • Bedford JJ, Weggery S, Ellis G, McDonald FJ, Joyce PR, Leader JP, and Walker RJ. Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride.ClinJ Am Soc Nephrol 3: 1324-1331, 2008.
  • Berney-Meyer L, Putt T, Schollum J, and Walker R. Nephrotoxicity of recreational party drugs.Nephrology 17: 99-103, 2012.
  • Ting YT, Coates PT, Walker RJ, and McLellan AD. Urinary tubular biomarkers as potential early predictors of renal allograft rejection.Nephrology 17: 11-16, 2012.
  • Vos FE, Schollum JB, Coulter CV, Doyle TC, Duffull SB, and Walker RJ. Red blood cell survival in long-term dialysis patients. Am J Kidney Dis 58: 591-598, 2011.
  • Walker RJ, Leader JP, Bedford JJ, Gobe G, Davis G, Vos FE, deJong S, and Schollum JB. Chronic interstitial fibrosis in the rat kidney induced by long-term (6-mo) exposure to lithium.Am J Physiol Renal Physiol 304: F300-307, 2013.


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