Seminar: Prof. Tony Durston

Origins of the vertebrate main body axis

23 April 2013 00:00 hrs.
Location see remarks
Origins of the vertebrate main body axis

Prof. Tony Durston, University of Leiden, The Netherlands


Prof. Gert Jan Veenstra, department of Molecular Developmental Biology, NCMLS

23-04-2013 00:00:00Europe/AmsterdamOrigins of the vertebrate main body axis Location see

Remarks / more information:

Durston, TonyWe have evidence  that the main body axis arises during gastrulation via a timing mechanism.  In Amphibia, a timer in the non organiser mesosderm (NOM) interacts with the Spemann organiser (SO) which stabilises an anterior to posterior sequence of positional identities at sequentially later times. We have evidence suggesting that the timer works via Hox temporal collinearity (which is evident in the NOM and unchanged in organiserless embryos) and that the positional identities are defined by Hox codes. Hox temporal collinearity involves positive and negative interactions among Hox genes and is timed by the embryo's segmentation clock. 

One thing that is important in this mechanism is the organiser dependent transmission of positional information from NOM mesoderm to neurectoderm (NE). It is possible that this process mediates stabilisation of positional information. We have shown that it occurs via non cell autonomous Hox autoregulation, via an ancient signalling mechanism involving the physical transfer of Hox proteins from cell to cell. 

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